TL;DR: We adapted our protein language model ProGen to optimize antibodies that bind to a protein called “CD40L”, a critical target for autoimmune disorders. We tested our AI designed antibodies in the laboratory and found that they bound very tightly to CD40L, showcasing the potential of this approach for

AI can learn the language of biology to create artificial proteins across multiple protein types that are functional and unseen in nature.

We use smaller language models as generative classifiers to guide generation from larger language models. We show that this method can make generations friendlier, reduce bias and toxicity, and achieve zero-shot controllable generation of unseen topics.