Using language models to design antibodies to combat autoimmune disorders

TL;DR: We adapted our protein language model ProGen to optimize antibodies that bind to a protein called “CD40L”, a critical target for autoimmune disorders. We tested our AI designed antibodies in the laboratory and found that they bound very tightly to CD40L, showcasing the potential of this approach for

13 Oct 2023 •

GeDi: A Powerful New Method for Controlling Language Models

We use smaller language models as generative classifiers to guide generation from larger language models. We show that this method can make generations friendlier, reduce bias and toxicity, and achieve zero-shot controllable generation of unseen topics.

22 Sep 2020 •